Noureddine Souirti
Department of Psychiatry and Neurology, Medical University of Vienna, Austria
Title: ASSESSMENT OF SLEEP- WAKE PATTERNS IN LESCH‘S TYPE 1 AND TYPE 2 TOBACCO DEPENDENTS
Biography
Biography: Noureddine Souirti
Abstract
Correlation between smoking and sleep interruptions have been documented in many research papers. Misalignment in the mechanisms of the suprachiasmatic nucleus (SCN), the hypothalamic– pituitary adrenal axis (HPA), or hypothalamus interferes negatively in producing sleep disorders. Earlier animal studies showed that nicotine influences the circadian system via stimulating the nicotinic acetylcholine receptors (nAChRs) in SCN of the hypothalamus. The stimulation of nicotine to the HPA axis leads to the secretion of corticotropin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus. This secretion stimulates the production of adrenocorticotropic hormone (ACTH) in the pituitary gland and hence leads to the increased secretion of cortisol by the adrenal gland. Sleep neurotransmitter like GABA and melatonin can be suppressed either through the inhibition of nicotine to neurons in SCN or through the stimulation of nicotine to the HPA functions by increasing the secretion of serotonin, dopamine, and noradrenaline. The purpose of this study is to investigate the relationship of tobacco and sleep disorders in Lesch typology, which is a clinical classification of four types of addicted patients to tobacco based on their level of addiction and clinical severities. Building on our previous data, we assume to see insomnia disorder in type 1 smokers who may have less total sleep time (TST), longer sleep latency, high REM sleep density, in comparison with type 2 and the control group. In this investigation, the Lesch European Smoker Classification instrument and test of biomarkers will be used to assess the tobacco abuse. To assess the sleep structure we aim to use actigraphy in combination with sleep log and polysomnography (PSG).